To do an update on a piece of software I downloaded VB Express 2010. Converted my project and started hacking away. I found that none of my breakpoints would fire as “no symbols have been loaded for this document”. Upon a little investigation it appeared the project was in “Release” mode. A mode that was in older version of Visual Studio but removed from Visual Basic Express 2008. Now getting it to change to debug mode, I had to dig the button from a context sensitive menu and add it to the standard tool bar.
View -> Toolbars -> Customize
Commands -> Toolbar -> Standard
Build -> Configuration Manager
Now you can use the Configuration Manager to change the mode from release to debug, and back again!